Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy
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چکیده
منابع مشابه
Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy.
Regulation of STAT3 activation is critical for normal and malignant hematopoietic cell proliferation. Here, we have reported that the endogenous transmembrane protein upstream-of-mTORC2 (UT2) negatively regulates activation of STAT3. Specifically, we determined that UT2 interacts directly with GP130 and inhibits phosphorylation of STAT3 on tyrosine 705 (STAT3Y705). This reduces cytokine signali...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2016
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci84620